Urology Research & Practice
PEDIATRIC UROLOGY - Clinical Trial

Effect of Prunus cerasus (Sour Cherry) on Nephrolithiasis in Children: The First Noninferiority Two-Arm Randomized Clinical Trial

1.

Department of Pediatrics, Mashhad University of Medical Sciences Faculty of Medicine, Mashhad, Iran

2.

Mashhad University of Medical Sciences, Faculty of Medicine, Mashhad, Iran

3.

Clinical Research Unit, Mashhad University of Medical Sciences, Mashhad, Iran

Urol Res Pract 2024; 50: 134-138
DOI: 10.5152/tud.2024.23206
Read: 136 Downloads: 70 Published: 31 March 2024

Objective: The present study evaluated the effect of Prunus cerasus (sour cherry) on children with nephrolithiasis.

Method: We conducted a randomized noninferiority controlled trial to evaluate the therapeutic efficacy of P. cerasus among children with nephrolithiasis. Subjects in the intervention group received 1.25 mL/kg of cherry concentrate once daily for 2 months, while the control group received 1 mL/kg Polycitra-K, which consists of 220 g citrate potassium and 68 g citric acid in 1000 mL sterile water. The major outcome was sonographically determined number and sizes of kidney stones, which were assessed before and after the trial.

Results: Sixty-eight children completed the study. At trial onset, both groups were similar in baseline characteristics (P > .05). In within-group analysis, the number of stones significantly decreased in both groups (P < .05). After 2 months, the number of nephrolithiasis was 1.55 ± 0.49 and 1.47 ± 0.67 in the control and intervention groups, respectively (P value=.56). The percentage of change in calculi number was 44.11 ± 11.12 and 38.14 ± 14.08 in the control and intervention groups, respectively (P value=.08). At the end of the study, the urine pH was 6.46 ± 0.99 and 6.14 ± 0.83 in the control and intervention groups, respectively (P value=.19). Urine calcium and uric acid concentrations were 32.00 ± 12.32 and 28.95 ± 10.96 mg/mm (P value=.68) and 24.11 ± 10.58 and 30.03 ± 11.39 mg/mm (P value=.012) in control and intervention groups, respectively.

Conclusion: Our clinical data supported the efficacy of sour cherry in the treatment of nephrolithiasis compared to Polycitra-K. Future randomized controlled trials are needed to confirm the present observation.

Cite this article as: Ghane-Sharbaf F, Reza-Jafar Z, Bakhtiari E, Saadat S. Effect of Prunus cerasus (sour cherry) on nephrolithiasis in children: The first noninferiority two-arm randomized clinical trial. Urol Res Pract. 2024;50(2):134-138.

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