Urology Research & Practice

Oligometastatic Prostate Cancer: Is there a Role for Surgery? A Narrative Review


Department of Urology, Nuovo Ospedale Civile di Sassuolo, Modena, Italy


Division of Urology, Portogruaro Hospital, Venice, Italy


Division of Diagnostic Immaging, Department of Medicine and Surgery, S. Maria della Misericordia Hospital, Perugia University, Italy

Urol Res Pract 2022; 48: 174-179
DOI: 10.5152/tud.2022.22064
Read: 999 Downloads: 306 Published: 01 May 2022

Oligometastatic prostate cancer is commonly considered a transition between high metastatic and local- ized disease and includes a large spectrum of conditions with a polymorphic clinical behavior. The current management of these patients contemplates systemic therapy (i.e., androgen-deprivation drugs, chemothera- peutic drugs, or both treatments administered simultaneously) which have been shown to improve survival. Radiotherapy has also been introduced, into a multimodal setting, among the therapeutic treatments forpatients who are defined as oligometastatic prostate cancer according to Chemohormonal Therapy Versus Androgen Ablation Randomized Trial for Extensive Disease in Prostate Cancer (CHAARTED) criteria.The role of surgical debulking in patients with oligometastatic prostate cancer has always been considered impracticable, both for a marginal therapeutic role and for the greater risk of sequelae and/or complications related to the procedure itself. Several authors have demonstrated some mechanisms by which the persistence of the primary tumor can facilitate the clinical progression of the disease itself and promote carcinogenesis, differentiation, migration, and angiogenesis in prostate cancer. From these studies emerges the hypothesis of a possible therapeutic advantage in oncological terms also for cytoreductive radical prostatectomy, in a multimodal therapy setting, compared to systemic therapy alone. The present review summarizes the main knowledge regarding the safety, feasibility, and oncological outcomes of cytoreductive radical prostatectomy in oligometastatic prostate cancer patients.

Cite this article as: Martorana E, Bruschi M, Scialpi P, Grisanti R, Scialpi M. Oligometastatic prostate cancer: is there a role for surgery? A narrative review. Turk J Urol. 2022;48(3):174-179.

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