Abstract

The aim of this study is to evaluate the effect of alfuzosin, which is a selective alpha blocker on intraprostatic pressure by transrectal Doppler ultrasonography and if it is possible to use intraprostatic pressure as a dynamic parameter.

The urology outpatients applied with prostatic complaints were subjected to detailed history, international prostatic symptom score (IPSS), physical examination, routine biochemical examination and uroflowmetric evaluation. Twenty-seven patients diagnosed as benign prostatic hyperplasia (BPH) were evaluated by transrectal Doppler ultrasonography. After this examination, the patients were subscribed Alfuzosin tb 7.5 mg/day for 15 days. At the end of the treatment period, IPSS evaluation, uroflowmetry and transrectal Doppler ultrasonography were repeated.

The mean age of the 27 patients was 61.70±7.51 (45-73). The mean (±SEM) IPSS, Qmax and Qave values of the patients before treatment were 14.16±1.19, 13.84±1.51 and 6.05±0.66 respectively whereas they were 9.44±0.44, 16.45±1.25 and 7.36±0.72 after treatment. The uroflowmetry values before and after treatment were statistically different (p<0.05). Central end diastolic velocity (CEDV) and central resistivite index (CRI) were 4.30±0.54 and 0.69±0.018 before treatment and they were 4.73±0.60 and 0.65±0.020 after treatment by transrectal Doppler ultrasonography. These results were statistically significant. There was no statistically significant difference in other parameters measured from central and peripheral zones (p>0.05).

As a result of transrectal Doppler ultrasonography evaluation, we propose that the alpha-blocker alfuzosin is efficient to decrease intraprostatic pressure and measurement of the resistivite index and central end diastolic velocity can be used to evaluate dynamic component of the prostate.