Abstract

We determined the correlation between recurrence and overexpressions of p53 and Ki-67 in the prognosis of stage pTa, G1-2 superficial urothelial cell bladder cancers regraded according to the classification of 1998 WHO/ISUP Consensus.

Forth eight patient who were diagnosed to have primary superficial urothelial cell bladder cancer (stage pTa,G1-2) between January 1995 and December 1999 were examined retrospectively. Subgroups of patients were as follows: 1-Urothelial papilloma (UP): 7 (14,6%), 2-Papillary Urothelial Neoplasm of Low Malignant Potential (LMP): 16 (33.3%), 3-Papillary Urothelial Carcinoma, Low grade (LG): 14 (29.2%), 4-Papillary Urothelial Carcinoma, High grade (HG): 11 (22.9%). Mean percentage values of p53 and Ki-67 (immunreactivity index) were found as 2,5 and 3,8% in UP; 6,6 and 8% in LMP; 19,9 and 19,7% in LG; 35,1 and 30,1 in HG respectively. If threshold percentage value of p53 were taken as 22%, 13 cases were positive and 4 cases were negative in recurrent group. When threshold percentage value of Ki-67 was taken as 10%, 15 cases were positive and 2 cases were negative in recurrent group.

When tumor markers such as p53 and Ki-67 were together with other criteria, not even by their own, we concluded that superficial bladder tumors, which have high recurrency rate and progression risk, can be differentiated from others and so that proper cure and observation frequency can be planned according to this.