Abstract

Because of the high incidence and recurrence rate, safe and noninvasive methods are needed for early diagnosis and following in bladder cancer. We investigated the value of the urinary NMP22 and urine cytology for diagnosis of bladder cancer.

We have selected a group of 43 patients (37 males and 6 females, mean age 61.27yrs) with TCC of bladder, and a control group of 37 patients (27 males and 10 females, mean age 54.35yrs). Sensitivity, specivity, positive and negative predictive value and accuracy rate are compared for both group. ELISA NMP22 (Matritech) technique is specific for the nuclear mitotic apparatus protein expressed by cancer cells. In this test the cutoff was 10.0 U/ml.

The mean NMP22 values were 48.38 in patients with TCC and 6.23 in control group. Of 43 patients with TCC, 35 had a superficial (pTa, pT1) and 8 an invasive tumor. The median NMP22 values were 31.88 in the patients of superficial group and 120.5 in invasive tumors. The sensitivity and specivity were found 86% and 75.6% in NMP22 test while 46.5% and 94.5% in cytology.

Sensitivity, negative predictive value and accuracy rate are higher for NMP22, while specivity and positive predictive value are higher for cytology.