THE ANALYSES RESULTS OF Y CHOROMOSOME MICRODELETIONS IN IDIOPATIC SEVERE OLIGOZOOSPERMIC AND AZOOSPERMIC INFERTILE MALES

Introduction: We studied the analyses results of Y chromosome microdeletions in idiopatic severe oligozoospermic and azoospermic infertile males in Turkish population.

Materials and Methods: 28 infertile patients who admitted to Department of Urology of Gülhane Military Medical Academy were divided into 4 groups as azoospermia, severe oligozoospermia, oligozoospermia and normozoospermia according to their semen parameters. Testis biopsies were performed in azoospermic patients. Serum FSH, LH, prolactin and testesteron levels were measured. After these examinations, patients without varicocele, ejaculatory dysfunction, endocrinopathies, gonadotoxin related dysfunction, infection were classified as ‘idiopathic infertile’. Y chromosomal microdeletions were studied by YDDS (Y Deletions Detection System) in patients having idiopathic severe oligozoospermic and azoospermic patients.

Results: Microdeletions were found in 7 of 29 patients. 5 of which were azoospermic and 2 were severe oligozoospermic. These were no statistical difference in FSH levels between patients with or without deletions (p=0.183; p=0.602). All patients had deletions on AZFc region and none of them had on AZFc region. Two patients the same deletions, but their testicular phenotype was different from each other. One patient having deletion on AZFc+AZFd+AZFb region had a testicular phenotype of hypospermatogenesis. However, one patient having deletion only on one STS had a testicular phenotype of Sertoli cell only and spermatositik arrest.

Conclusion: Most of idiopathic infertile men had Y chromosome microdeletion. As there wasn’t a relation between testicular phenotype and microdeletion, no data could be obtained about treatment options.